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Donatella Boschi Selected Research

Dihydroorotate Dehydrogenase

6/2022Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia.
6/2022Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study.
2/2021The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia.
1/2021Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety.
1/2021Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication.
1/2018Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy.

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Donatella Boschi Research Topics

Disease

6Neoplasms (Cancer)
06/2022 - 12/2009
4Prostatic Neoplasms (Prostate Cancer)
07/2022 - 10/2017
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2022 - 07/2018
2Infections
08/2021 - 01/2021
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2022
1Multiple Myeloma
06/2022
1Bacterial Infections (Bacterial Infection)
06/2022
1Ischemic Stroke
12/2021
1Encephalitis (Encephalitis, Rasmussen)
12/2021
1Fever (Fevers)
12/2021
1Stroke (Strokes)
12/2021
1COVID-19
08/2021
1Herpes Simplex
01/2021
1Leukemia
07/2018
1Multiple Sclerosis
01/2018
1Parasitic Diseases (Parasitic Disease)
01/2018
1Rheumatoid Arthritis
01/2018
1Malaria
01/2018
1Autoimmune Diseases (Autoimmune Disease)
01/2018
1Carcinogenesis
12/2009
1Colonic Neoplasms (Colon Cancer)
12/2009
1Cardiotoxicity
07/2005

Drug/Important Bio-Agent (IBA)

6EnzymesIBA
07/2022 - 10/2017
6Dihydroorotate DehydrogenaseIBA
06/2022 - 01/2018
4pyrimidineIBA
06/2022 - 01/2018
3Aldo-Keto ReductasesIBA
07/2022 - 10/2017
3AndrogensIBA
07/2022 - 10/2017
2MEDS433IBA
08/2021 - 01/2021
2Antiviral Agents (Antivirals)IBA
08/2021 - 01/2021
2Pharmaceutical PreparationsIBA
06/2018 - 12/2009
2Testosterone (Sustanon)FDA Link
04/2018 - 10/2017
2Protein Isoforms (Isoforms)IBA
04/2018 - 10/2017
2enzalutamideIBA
04/2018 - 10/2017
2abirateroneIBA
04/2018 - 10/2017
1Tyrosine Kinase InhibitorsIBA
06/2022
1Flavin Mononucleotide (FMN)IBA
06/2022
1LigandsIBA
06/2022
1Biological ProductsIBA
06/2022
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2021
1Dihydrotachysterol (AT 10)IBA
12/2021
1Dinoprostone (PGE2)FDA Link
12/2021
1Interleukin-6 (Interleukin 6)IBA
12/2021
1NF-kappa B (NF-kB)IBA
12/2021
1Biomarkers (Surrogate Marker)IBA
04/2021
1Dipyridamole (Persantine)FDA LinkGeneric
02/2021
1diphenyl (biphenyl)IBA
01/2021
1NucleosidesIBA
01/2021
1pyridineIBA
01/2021
1Indomethacin (Indometacin)FDA LinkGeneric
04/2019
1brequinarIBA
07/2018
1Phosphotransferases (Kinase)IBA
06/2018
1Prostate-Specific Antigen (Semenogelase)IBA
04/2018
1Agrochemicals (Agricultural Chemicals)IBA
01/2018
1Celecoxib (Celebrex)FDA Link
12/2009
1Cadherins (E-Cadherin)IBA
12/2009
1beta CateninIBA
12/2009
11,2,5-oxadiazole 2-oxideIBA
07/2005

Therapy/Procedure

3Therapeutics
01/2021 - 10/2017
2Castration
07/2022 - 10/2017
1Critical Care (Surgical Intensive Care)
07/2018